All four southwestern deserts. Southern Nevada, extreme southwest Utah, southeastern California, southern third of Arizona, southern New Mexico, into west Texas and south into Mexico.
Habitat
Well-drained slopes and plains, especially those with a layer of caliche, up to 4,000 feet. Often the most abundant shrub, even forming pure stands.

Flowers
Inch-wide twisted, yellow petals bloom from February-August. Some individuals maintain flowers year round. After the Creosote blooms the flower turns into a small white fuzzy fruit capsule that has 5 seeds. You can find these seed capsules on the ground under the creosote bushes.
Fruit
Globose, hairy, reddish-white.
Description
The Creosote Bush is the most characteristic feature of North America's hot deserts. It is one of the best examples of a plant that tolerates arid conditions simply by its toughness. It competes aggressively with other plants for water, and usually wins, accounting for its prevalence in many arid locations of the southwest.